What you eat determines what your body becomes. Athletes intuitively understand this linkage?the harder you're training the more you need to eat. While the best answer to any nutritional question is to start with a balanced diet, at the margin there is a role for supplements. These might include a multivitamin as insurance against any deficiencies or antioxidants to minimize oxidative damage.

One area that's only recently gotten much notice is the role of nucleotides?the building blocks of DNA/RNA.

Beginning in the 1980s, doctors working with kidney transplant patients noticed that increased nucleotides in the diet resulted in a strengthening of the immune system. This concerned them because transplant patients must have their immune systems suppressed to avoid rejection of the transplanted organ.

These observations spurred additional research along several avenues. Numerous animal studies confirmed a link between nucleotides in the diet and immune function.

In humans, it was noticed that breast milk has high levels of nucleotides and as a result several infant formulas now include supplemental nucleotides. A second line of research in humans looked at nucleotide supplementation as a means to boost the immune system and expedite healing in surgical patients. There now exist various clinical nutritional products in this category of immune enhanced diet.

An important study of nucleotide supplementation in athletes was conducted by Lars McNaughton at the University of Hull in the UK. The study looked at two indicators, immunoglobin and cortisol, to gauge the effect of nucleotide supplementation on immune system function and recovery.

They found significant results for both indicators:  higher levels of immunoglobin and lower levels of cortisol, after exercise.  Higher levels of immunoglobin confirmed enhancement of the immune system, and lower levels of cortisol supported faster recovery (since cortisol is a catabolic stress hormone, lower levels following exercise mean less tissue damage during and subsequent to the exercise session, and thus a faster recovery).

A key question in this is the relation of the immune system to recovery. While they may sound distinct, it is actually the immune system that mediates the recovery process.

Training imposes a stress upon the body with the object of provoking a particular adaptation, for example, increased vascularization or strengthened muscles. Training stress takes the form of an injury, like micro-tears in the muscle tissue, which upon healing produce the desired training adaptation of strengthened muscles. It is the immune system which provides the signaling to recognize, initiate and manage these responses.

What does this mean for athletes? There are no definitive recommendations for nucleotide consumption or supplementation. While your body normally synthesizes the majority of the nucleotides it needs, stress increases the utilization of nucleotides from dietary sources.

nuBound provides a convenient, concentrated source of nucleotides derived from brewer's yeast and packaged in easy-to-take capsules.

Guaranteed free from banned substances
(including all substances on the lists of the
World Anti-Doping Association, WADA; and/or
the National Collegiate Athletic Association,
NCAA).

 nuBound contains only the highest-quality
pharmaceutical-grade ingredients.

 Satisfied the U.S. Food and Drug
Administration (FDA) regulatory requirements
on March 22, 2006.

Directions:  The normal supplementation dosage for nuBound is 4 capsules
daily, usually taken as 2 capsules in the morning and 2 in the evening (or following
exercise).  

In circumstances where your body is under extraordinary stress, you can increase
the dosage to provided added benefit.  In the days prior to, during and following
competition or periods of heavy training (eg, double workouts or extended long runs)
you can safely double the recommended daily dosage to mitigate this elevated stress.

Should you feel the onset of a cold or the flu, you should immediately take 8-12
capsules and then continue taking 8 capsules daily for three days after the
symptoms have passed.

If you are allergic to yeast, have an autoimmune disease, are affected by gout or are
an organ transplant recipient, please consult your health care professional before
taking this product.

Keep out of reach of children.  Store in a cool dry place.