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"I think you guys [gals ?] are the best. Free shipping on hammer products and super fast service. What's not to like?"

Nancy H.


Proline Sports Nutrition & Equipment,

I was shopping for the product below using Google as which time I saw your Google add. This was the first I heard of your company. I went to your site and liked what I saw and proceeded to order the Optygen HP. The order was placed on late Friday afternoon and was delivered (to my surprise) on Saturday. Your service is awesome as well as your price match guarantee. There is no doubt that I will continue to use you in the future, as well as recommend you to others.


Brian H
Aurora, IL
 I am very impressed with your customer service.  I was worried about getting my order with a marathon a week and a half out.  Wow, less than 24 hours and my order was sitting on the porch.  That is phenominal service.  I will definately shop with you again.  I have had free shipping take 10 days.  Proline Sports Nutrition is a site I will recommend to my many running/cycling buddies.  Thanks for the great response.  BTW, that info on the Hammer Nutrition products was wonderful!!  It helped me hone in on my nutrition/hydration plan for my marathon.  I printed off the entire 120 pages!  This is my 4th marathon.  I've trained hard, and my Hammer plan I do believe will give me a PR.

2019 Optygen HP New & Improved Endurance Formula by First Endurance (2019 Optygen HP)

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The all-New and Improved OptygenHP formula features 23% improvement in endurance capacity and a significant increase in energy (ATP) production. Athletes who participated in these studies were able to replenish glycogen faster, which leads to improved recovery and improved performance on back-to-back workouts and during heavy training. In addition, subjects experienced less muscle inflammation after high-intensity exercise, resulting in less soreness and faster recovery.

First Endurance introduced the world to Optygen back in 2002. Since then, there have been a number of additional studies done that show Optygen reduces cortisol levels. By modulating cortisol, athletes experience better recovery, an increase in VO2, improved oxygen utilization and enhanced performance.

The new OptygenHP now delivers 50% more beta-alanine. A 2012 study evaluated the effects of beta-alanine supplementation on VO2max, time to exhaustion and lactate concentrations. Subjects supplemented with beta-alanine for six weeks. The group experienced a significant increase in VO2max, an improvement in time to exhaustion and lactate utilization. The study concluded that beta-alanine supplementation can reduce lactate concentrations during exercise and thus can improve exercise performance in endurance athletes.


Dosage recommendations: Take 4 capsules daily with a meal.

*Daily Value Not Established

Other Ingredients: gelatin red capsules

Chelavite is a registered trademark of Albion laboratories, Inc.
Covered by Albion international, Inc., U.S. Patent 5,614,553.
OptygenHP is designed to be a multifaceted formula with a mechanism of action that is directly related to an improvement in key physiological facets of hard training. Each key mechanism of action has been tested on endurance trained human subjects and further supported by studies done on the complete formula. These mechanisms are:

  1. Cortisol: Optygen/Rhodiola reduces the primary stress hormone cortisol. This also relates to improvements in the cortisol/testosterone ratio. With hard training, stress is increased and hence cortisol is increased. Chronically elevated levels of cortisol lead to overtraining syndrome, suppressed testosterone, poor recovery, poor sleep, catabolism of muscle and poor performance. Optygen and Rhodiola have clearly proven significant modulation of cortisol and improvement in cortisol/testosterone ratio in hard training athletes.
  2. Glucose Tolerance Factor: Chromium has been shown in various studies to modulate Glucose Tolerance Factor leading to a modulation in blood glucose. Athletes can experience a more steady supply of energy with no wild sugar swings.
  3. Adenosine Tri Phosphate (ATP) production: Studies on OptyMax (ES, PN, RR) and Rhodiola extract have all shown an improvement in Adenosine TriPhosphate production. ATP is the primary energy source of the human body. Reduction in ATP leads to fatigue. This ATP production is further supported 13 through the Optygen proprietary ATPro base consisting of the precursors of ATP production, calcium pyruvate, sodium phosphate, potassium phosphate and ribose.
  4. Recovery/Inflammation: Studies on OptyMax (PN, RR) fruit extract have clearly shown reduction in the key recovery markers measured by MDA analysis, IL-6 and CK. These improved markers mean less soreness, less muscle catabolism and improved recovery from hard training.
  5. Glycogen Sparing: Studies on Eleutherococcus senticosus extract and Rhodiola Rosea extract have shown a significant reduction in glycogen use during exercise. Athletes can spare glycogen leading to improved endurance and improved substrate utilization.
  6. Glycogen Re-synthesis: Studies on OptyMax (PN, RR) fruit extract have shown a significant improvement in the replenishing of glycogen following exhaustive exercise. Improved glycogen re-synthesis means faster recovery and improved performance on back-to-back-to-back hard training days. It’s also important to note that these benefits are experienced with lower insulin levels.
  7. Lactate curve: Studies on Optygen, Rhodiola and Beta-Alanine have shown significant improvements in lactate threshold. Beta-Alanine’s primary mechanism of action is to increase the limiting rate of lactate synthesis so lactic acid build up does not slow performance. An improved lactate curve means athletes can hold a faster pace before reaching anaerobic threshold.

1.  How is this formula different than OptygenHP?  This prototype formula has two key changes:

a) The amount of Beta-Alanine has been increased by 50% so there’s now 1.5 grams/serving.

b) Cordyceps has been replaced with a special proprietary matrix of Eleutherococcus senticosus extract, Panax notoginseng and Rosa Roxburghii fruit extract.  There are a number of new studies that have been done on endurance athletes that show significant endurance benefits.

2.  What’s the purpose of this OptygenHP Prototype? When we introduced the last version of OptygenHP, it was based on all the latest research and clinical studies that was available at that time.  Since then, new research and new clinical studies have become available.  The purpose of this new OptygenHP prototype is to get it in the hands of First Endurance sponsored athletes for a hands-on evaluation so they can give us input and feedback, good or bad.  At this point, we have not  decided whether to proceed with an OptygenHP formula change.

**It’s important to note that this is only a prototype and is only in an initial testing phase.  First Endurance constantly reviews the latest research and evaluates the most recent clinical studies and updates existing formulas if it will improve our product line. Developing a prototype is one of the first steps First Endurance takes to determine if a formula change should be considered.

3.  What should an athlete notice?  The new studies show significant improvement in various physiological and performance areas of endurance.  Athletes should notice an increased ability to handle high volume and high intensity training.  Athletes should be able to replenish glycogen faster leading to improved recovery and improved performance on back-to-back workouts and during months of heavy training.   Athletes should expect inflammatory response to high intensity exercise to improve leading to faster recovery.    The studies have proven:

-Improved glycogen re-synthesis

-Improved inflammatory response and recovery markers (less sore)

-Increase in ATP production

-Sparing of glycogen during exercise

-Improved exercise capacity

-Improved lactate curve

-Improved insulin sensitivity

4.  When will it be available?  First Endurance will make the prototypes available exclusively to newsletter subscribers on March 11, 2013. We did a very small sample run of the new OptygenHP prototypes.  While the majority of these samples have been given to sponsored athletes, there is a small quantity of extra bottles available.  Once they’re gone, they’re gone.

5.  What is the special proprietary matrix?  The proprietary matrix consists of three key nutrients.  This nutrient blend is only available in the new OptygenHP product.   The blend consistes of Eleutherococcus senticosus (ES) extract, highly fractionated Panax notoginseng (PN) extract and Rosa Roxburghii (RR) fruit extract.

Following exhaustive exercise, athletes fight inflammation, battle oxidative stress, need to repair torn muscle tissue, and have depleted essential glycogen stores. Glycogen is the primary storage carbohydrate in muscles and liver totaling approximately 2,000Kcal in a trained athlete. Muscle glycogen is generally known as the main fuel for strenuous sports activity. Unlike fat, this fuel can be mobilized rapidly under anaerobic condition, which typically occurs under various acute/exhaustive physical exercises.

Glycogen re-synthesis is the process of converting consumed food into stored glycogen. Even with optimal recovery after a hard workout, full glycogen re-synthesis is difficult to attain within 24 hours and subsequent workouts can begin to suffer. This is especially true when working out or racing for multiple days back to back. Having the ability to replenish glycogen to a greater degree allows athletes to bounce back from exhaustive exercise faster and be better prepared for the next day of training or racing.

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