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Optygen Q&A

Q & A

  • How will OPTYGEN help me race better?
  • How long does it take before I start noticing the benefits?
  • When should I take OPTYGEN?
  • How long will a bottle last?
  • Is OPTYGEN legal?
  • What is a "Certificate of Analysis" and why is it important?
  • Will OPTYGEN help me recover faster?
  • Why are the capsules red?
  • Why is the bottle glass instead of plastic?
  • Why does OPTYGEN have Cordyceps and Rhodiola Rosea?
  • Should I cycle on and off with OPTYGEN?
  • Is it OK to use Optygen everyday even though it has phosphates in the formula?
  • Are First Endurance products safe from Cross Contamination?
  • Do the adaptogen's Rhodiola and Cordyceps in Optygen cause hypertension or cramping?






  • Q: How will OPTYGEN help me race better?

    A: OPTYGEN will dramatically improve your training and recovery. OPTYGEN is designed to help you through your most intense training and racing. The OPTYGEN formulation is based on the latest human clinical research. The research has shown the following endurance benefits.
  • Increases Endurance and Performance
  • Reduced Lactic Acid
  • Increases oxygen utilization
  • Increase in VO2 Max
  • Increase in Time to Exhaustion
  • Increase Anaerobic threshold
  • Improved exercise capacity
  • Increase Maximal Oxygen uptake
  • 30% - 50% increase in Oxygen Utilization
  • Increase ratio of ATP by 45% - 55%
  • Enhanced Endurance
  • Increase in ATP production





  • Q: How long will it take before I start noticing the benefits?

    A: You should start experiencing the benefits of OPTYGEN approximately six (6) days after you start taking OPTYGEN.




    Q: When should I take OPTYGEN?

    A: It is best to take Optygen in the morning with a meal.




    Q: How long will a bottle last?

    A: OPTYGEN has a 7-day loading phase. Because of this, the first bottle will last 23 days. After the loading phase has been done, each bottle is a 30-day supply.




    Q: Is OPTYGEN legal?

    A: First Endurance is committed to developing the most advanced endurance supplements on the market. First Endurance has taken additional measures to assure that our products are safe legal and stimulant free. First Endurance supplements are legal to use in any sporting event governed by the World Anti-Doping Association (WADA), the US anti-doping association (USADA) and by the UCI (Union Cycliste International). One or more of the aforementioned governing bodies govern all US Cycling, International Cycling, US Triathlon and International Triathlon.

    Some commonalties among these governing bodies include banned substances which fall into one or more of the following categories as listed in Section I A-E of the UCI Prohibited Classes of substance and Prohibited Methods document. A) Stimulants B) Narcotics C) Anabolic agents D) Diuretics and E) Peptide hormones, mimetics and analogues. This document goes on to list banned substances within each of these classes. Regulations also ban 'Compounds chemically or pharmacologically related to the products mentioned'.

    OPTYGEN contains NO ingredients, which are explicitly listed under the banned substance list, nor are any of the ingredients related chemically or pharmacologically. First Endurance has also contacted the USADA and received verbal confirmation that our ingredients are not banned based on their regulations. Note: USADA, WADA and UCI do not offer any certification or written confirmation.

    First Endurance manufactures its formulations to the highest GMP (Good Manufacturing Practice) standards available. In addition we use a proprietary manufacturing method for added safety and assurance. Following the Supplement Facts panel you will notice we list 'NO processing aids' under Other Ingredients. The only ingredients found in Optygen, are those listed in the Supplement Facts Panel.

    Part XIV Article 7 of the Anti-doping Examination Regulations contains the following warning: riders must refrain from using any substance, foodstuff or drink of which they do not know the composition. It must be emphasized that the composition indicated on a product is not always complete. The product may contain prohibited substances not listed in the composition.

    For a complete list of regulations and banned substances please use one of the following links:
    UCI Banned Substance List
    WADA
    USADA




    Q: What is a "Certificate of Analysis" and why is it important?

    A: A Certificate of Analysis (C of A) is a document which states every active and inactive substance used to manufacture a product. A C of A also shows that there are no additional ingredients added to the OPTYGEN formulation. In order to assure the safety and efficacy of OPTYGEN, First Endurance provides a C of A with every bottle of Optygen.




    Q: Will OPTYGEN help me recover faster?

    A: Yes, it will help you recover. Because OPTYGEN will help you adapt during times of maximum stress, it also aids in recovery.




    Q: Why are the capsules red?

    A: capsules are dark red, not clear, to further reduce UV light degradation ensuring the highest quality, potency, and purity.




    Q: Why is the bottle glass instead of plastic?

    A: OPTYGEN is packaged in an amber glass bottle. Unlike plastic bottles, amber glass is an impermeable barrier that protects the product from harmful UV light and oxygen degradation.




    Q: Why does OPTYGEN have Cordyceps and Rhodiola Rosea?

    A: OPTYGEN utilizes two adaptagens that are the primary ingredients in the formulation. Patented Rhodiola Rosea and Cordyceps are both found and cultivated in Tibet. Both these herbs play critical roles in allowing the body to adapt to high levels of physical stress (similar to the stress a body is subject to when climbing Everest). It's these adaptations to hypoxia (lack of oxygen) which led researchers to also test its effects on elite endurance athletes. Both Rhodiola and Cordyceps have been clinically shown to increase VO2Max, lung function, oxygen utilization and anaerobic threshold significantly.




    Q: Should I cycle on and off with OPTYGEN?

    A: While there have been numerous clinical trials done that show the endurance benefits of the adaptogens cordyceps and rhodiola, there has never been a clinical trial done to study the effects of cycling on and off with adaptogens. All the clinical trials showed increased benefit through consistent use up to 12 weeks on adaptogens. Cordyceps and rhodiola have been used in Traditional Chinese Medicine for thousands of years. The Chinese claim that adaptogens (cordyceps & rhodiola) should be cycled on and off for maximum benefits. The theory is that your body builds up a tolerance to adaptogens over time (like your body builds up a tolerance to caffeine).

    First Endurance works very closely with the endurance athletes that use OPTYGEN. Most of the athletes who have been taking OPTYGEN have been using it for more than nine (9) months. They have tried taking OPTYGEN for a long period of time and they have tried cycling on and off with OPTYGEN. The majority of the athletes who cycled OPTYGEN noticed significant performance benefits when cycling three weeks on, one week off. Maximum benefits were experienced in training and racing during weeks two (2) and three (3).

    OPTYGEN works the best when you are maximizing lactic acid and/or heart rate. First Endurance recommends supplementing with OPTYGEN during hard training weeks and when you are preparing for a race, and to stop taking OPTYGEN when you are recovering from difficult training and not racing. OPTYGEN is well suited for periodization training.

    With the following schedule, a bottle of OPTYGEN will last thirty days:
    Week #1: Load six (6) capsules every day for seven (7) days
    Week #2: Take three (3) capsules every day for seven (7) days*
    Week #3: Take three (3) capsules every day for seven (7) days*
    Week #4: Stop taking OPTYGEN, easy week of training
    -Cycle again starting with week #1

    *For maximum benefit schedule key races during weeks #2 and #3.




    Q: Is it OK to use Optygen everyday even though it has phosphates in the formula?

    A: Through its role in 2,3 DPG synthesis, phosphorous may reduce lactate accumulation by enhancing oxygen release to tissues. The clinical research recommends taking 1g of sodium phosphate four times per day for at least three days leading up to a race. Prolonged use at a level of 4g per day may adversely affect calcium absorption. The research clearly indicates that sodium phosphate should be used acutely prior to a race.

    Optygen's ATPro matrix is designed to assure Adenosine Tri-Phosphate (ATP) production. All the ingredients in the ATPro matrix play critical roles in ATP formation, including Sodium and Potassium Phosphate. The phosphate levels used in Optygen on their own are not enough to elicit an ergogenic response, nor are they enough to affect PH balance or Calcium absorption.

    1) Res Q Exerc Sport 1990 Mar;61(1):80-4 Phosphate loading and the effects on VO2max in trained cyclists. Stewart I, McNaughton L, Davies P, Tristram S Centre for Physical Education, Tasmanian State Institute of Technology, Launceston, Australia

    2) Eur J Appl Physiol Occup Physiol 1996;72(3):224-30 The effects of acute phosphate supplementation in subjects of different aerobic fitness levels. Galloway SD, Tremblay MS, Sexsmith JR, Roberts CJ Faculty of Physical Education and Recreation, University of New Brunswick, Canada




    Q: Are First Endurance products safe from Cross Contamination?

    A: Since our primary market is elite endurance athletes we have everything to lose if someone were to test positive and trace it back to our product. Positive tests which have been traced back to supplements are always traced back to a supplement which does not directly market their products to Pro Endurance Athletes. I.E.. The bodybuilding supplements can legally sell androstenedione, DHEA, and precursors. Cross contamination that happens at the manufacturing site is not an issue with these companies. There is a level of tolerance set by the FDA which allows for a certain level of cross contamination. These supplement companies will manufacture an androstene type product, clean the blender and then manufacture an amino acid. The amino acid supplement may contain a small (parts per million) level of androstenedione.

    Realize that nothing is absolute. When you purchase any packaged food you have a risk of a contaminated product. Packaged foods, pharmaceutical companies, OTC products and supplements use many of the same ingredient suppliers. IE The cereal you eat in the morning is fortified with vitamins which come from the same supplier of vitamins found in your multivitamin. Some vitamin suppliers also supply pro-hormones. The key is to minimize your risk. First Endurance takes all the available steps to assure there is no cross contamination.

    At First Endurance we take all the necessary steps to prevent this.
    a) Our manufacturing and packaging facilities do not allow a single banned substance (except caffeine) to enter the facility.

    b) First Endurance requires a wet wash between products. FDA approved facilities require a high standard of cleanliness in order to minimize contamination. We take it a step further by requiring the machines, blenders to be cleaned with water.

    c) We source ingredients only from manufacturers who DO NOT supply pro-hormones. This eliminates the risk of cross-contamination at the supplier level.

    -Due to our level of concern, you can feel safer taking our product then your cereal.

    In addition, only FDA approved facilities require Certificate's of Analysis. These C of A's, are audited and reviewed by the FDA during their facility audits. A C of A assures that each of those ingredients have been tested for identity and only those ingredients are used in the product. First Endurance is the only supplement company which offers a C of A.


    Q: Do the adaptogen's Rhodiola and Cordyceps in Optygen cause hypertension or cramping?

    A: Absolutely not. The First Endurance research staff has done a thorough review of all the peer reviewed clinical studies and confirms that there is no evidence of hypertension or cramping. On the contrary, by definition adaptogen's allow the body to adapt to many physiological functions, including hypertension. In Supplementwatch.com's comprehensive review of the literature Optygen scored a 20 out of 20 on safety, again finding no evidence that this occurs.

    Resources for Today's Endurance Athletes

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    Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on this website. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this Website is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. ProLine Sports Nutrition, Inc. ®